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KMID : 0380020200350010010
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Korean Journal of Biotechnology and Bioengineering
2020 Volume.35 No. 1 p.10 ~ p.22
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Drug Delivery System Using Protein Nanoparticles
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Hong Se-Young
Park Hee-Ho
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Abstract
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Nanoparticles have various advantages as drug carriers, so they have been widely used to deliver various chemical and biomolecule drugs, such as anti-cancer drugs and therapeutic proteins. Among nanoparticles, protein nanoparticles are non-cytotoxic and biodegradable, with high potential as drug carriers. Protein nanoparticles can be synthesized using proteins such as silk protein fibroin, albumin, gelatin, gliadin, legumin, 30Kc19 protein derived from silkworm hemolymph, and are manufactured using methods such as emulsion/solvent extension, desolvation, electrospray technology, complexification, and etc. The characterization parameters of protein nanoparticles are particle size, particle morphology and structure, surface charge, drug loading and release, which vary the drug delivery efficiency according to these parameters. Thus, the synthesis of protein nanoparticles using various materials and manufacturing techniques is being actively studied to improve drug delivery efficiency.
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KEYWORD
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protein nanoparticle, drug delivery, biodegradable, therapeutic
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